Polygenic longevity score

1 paper5 findings

Effects

Brain MRI measures

no changein humans1

1 study

Polygenic longevity score has no effect on brain MRI measures in humans.
“We found no associations in the total sample.”
Humanstotal samplebrainn = 675
Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds
NPJ aging15 Oct 2026

Cortical thickness in pars triangularis, pars opercularis, and insula

upin humans1

1 study

Polygenic longevity score is associated with cortical thickness in pars triangularis, pars opercularis, and insula in humans.
“both PGLSs were associated with smaller WMHs volume and lower SVD burden, and a thicker cortex of pars triangularis, pars opercularis, and insula.”
Humansboth scores, with and without the APOE locuscerebral cortexmales
Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds
NPJ aging15 Oct 2026

Small vessel disease burden

downin humans1

1 study

Polygenic longevity score is associated with small vessel disease burden in humans.
“In males, both PGLSs were associated with smaller WMHs volume and lower SVD burden”
Humansboth scores, with and without the APOE locusbrainmales
Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds
NPJ aging15 Oct 2026

White matter hyperintensity volume

downin humans1

1 study

Polygenic longevity score is associated with white matter hyperintensity volume in humans.
“In males, both PGLSs were associated with smaller WMHs volume and lower SVD burden”
Humansboth scores, with and without the APOE locusbrain white mattermales
Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds
NPJ aging15 Oct 2026

Myocardial infarction

downin humans1

1 study