Cortical thickness in pars triangularis, pars opercularis, and insula

1. Polygenic longevity score is associated with cortical thickness in pars triangularis, pars opercularis, and insula in humans.

   “both PGLSs were associated with smaller WMHs volume and lower SVD burden, and a thicker cortex of pars triangularis, pars opercularis, and insula.”

   Humansboth scores, with and without the APOE locuscerebral cortexmales

   Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds

   NPJ aging·15 Oct 2026

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