Triglyceride-to-high-density lipoprotein cholesterol ratio

1. Triglyceride-to-high-density lipoprotein cholesterol ratio is associated with carotid plaque in humans (OR 1.11, 95% CI 1.07-1.15).

   “Both LDL-C (OR = 1.12, 95% CI: 1.08-1.17, P < 0.001) and TG/HDL-C (OR = 1.11, 95% CI: 1.07-1.15, P < 0.001) were independently associated with plaque.”

   Humanscross-sectional cohortn = 21,227

   Differential age-related patterns in the associations of LDL-C, TG/HDL-C ratio, and carotid plaque: a large-scale cross-sectional study in a Chinese health check-up population

   Frontiers in cardiovascular medicine·20 Jul 2026

1. Triglyceride-to-high-density lipoprotein cholesterol ratio raises the risk of type 2 diabetes in humans (HR = 1.29; 95% CI, 1.14-1.47; P < 0.01).

   “Regardless of adjustment for potential confounding variables, elevated TG/HDL-C ratio independently indicated a higher risk of incident T2DM [hazard ratio (HR) = 1.29; 95% confidence interval (CI), 1.14-1.47; P < 0.01.”

   Humansn = 2,571

   Triglyceride to High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio, a Simple but Effective Indicator in Predicting Type 2 Diabetes Mellitus in Older Adults

   Frontiers in endocrinology·24 Feb 2022

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