TG:HDL-C polygenic risk score

TG:HDL-C polygenic risk score is associated with memory decline in humans (β=0.003, p = 0.040).

“Additionally, a higher TG:HDL‐C PRS was associated with slower memory decline (β=0.003, p = 0.040; Figure 1).”

Humansadjusted for sex, baseline age, BMI, and APOE-ɛ4 positivityn = 10,806

Genetic associations between insulin resistance and memory performance/decline: A NACC cohort study

AAIC 2025 abstract·23 Dec 2025

TG:HDL-C polygenic risk score is associated with memory performance in humans (β=0.019, p = 0.009).

“A positive association was observed between genetic risk for TG:HDL‐C and baseline memory (β=0.019, p = 0.009).”

Humansadjusted for sex, baseline age, BMI, and APOE-ɛ4 positivityn = 10,806

Genetic associations between insulin resistance and memory performance/decline: A NACC cohort study

AAIC 2025 abstract·23 Dec 2025