4 papers4 findings
Cardiovascular disease
upin humans2HR 1.81
Triglyceride-glucose-body roundness index predicts cardiovascular disease in humans (AUC 0.557 (95% CI: 0.531 - 0.583)).
“TyG - BRI has a higher AUC of 0.557 (95% CI: 0.531 - 0.583) in ELSA and AUC of 0.581 (95% CI: 0.565 - 0.596) in CHARLS”
Humans12 yearsn = 3,256
AHA Scientific Sessions 2025 abstract3 Nov 2025
Triglyceride-glucose-body roundness index raises the risk of cardiovascular disease in humans (HR 1.81, 95% CI 1.09–2.98).
“the highest TyG-BRI group (Q4) had an increased risk of CVD compared with the Q1 group. (ELSA, HR 1.81, 95% CI 1.09–2.98”
Humanshighest quartile (Q4) vs lowest (Q1)12 yearsfemale: 54.0%sn = 3,256
AHA Scientific Sessions 2025 abstract3 Nov 2025
Triglyceride-glucose-body roundness index raises the risk of cardiovascular disease in humans (OR 1.251 (95% CI 1.139-1.373)).
“logistic regression analysis revealed a significant correlation between the TyG-BRI and the onset of CVD [odds ratio, 95% confidence interval: 1.251 (1.139-1.373) per 1 SD increase].”
Humansper 1 SD increase2011 to 2015n = 4,446
Frontiers in nutrition11 Jul 2025
Mortality
mixedin humans1
Triglyceride-glucose-body roundness index is associated with mortality in humans.
“TyG-BRI showed significant nonlinear associations with all-cause mortality in both cohorts.”
Humansatrial fibrillation without diabetes; UK Biobank and Jiangdu cohorts
Frailty and a metabolic measure linked to risk of death
BMC geriatrics8 Oct 2026
An observational study of 2,573 UK and 803 Chinese older adults with atrial fibrillation and no diabetes linked combined metabolic and frailty assessments to differing…An observational study of 2,573 UK and 803 Chinese older adults with atrial fibrillation and no diabetes linked combined metabolic and frailty assessments to differing death risks.