chromatin interactions are associated with transcriptional activity in mice.
“composition of short-range and ultralong chromatin contacts in individual cells is remarkably correlated with transcriptional activity, open chromatin state and genome folding density”
Experiments in cells from the soft centre of spinal discs identified a protein that promoted iron build-up, damage to fats and cell aging.Experiments in cells from the soft centre of spinal discs identified a protein that promoted iron build-up, damage to fats and cell aging.
Experiments in nucleus pulposus cells, tissues, and animal modelsMechanisms
Limit: Unreported sample sizes make the robustness of the disc-cell findings difficult to assess
Genetically modified newborn mice produced extra TRIM71, a protein that binds RNA, which promoted spontaneous regrowth of sound-detecting cells in the inner ear.Genetically modified newborn mice produced extra TRIM71, a protein that binds RNA, which promoted spontaneous regrowth of sound-detecting cells in the inner ear.
Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to transcriptional changes.Using genomic and transcriptomic profiling in male cancer cell lines, researchers mapped regional deletions and linked a new Y erosion score to transcriptional changes.