TNF-α and IL-6

1. Muscle stem cells decrease TNF-α and IL-6 in mice (D-galactose-induced accelerated aging in KM mice).

   “decreased TNF-alpha/IL-6”

   AnimalsD-galactose-induced accelerated aging in KM miceSerumWeekly administrationEight weeksfemales

   Muscle stem cells reduced organ injury in a mouse aging model

   Scientific reports·Oct 27, 2026

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1. Urolithin A decreases TNF-α and IL-6 in mouse cells (LPS-induced RAW 264.7 cells and periodontitis mice).

   “UA reduced IL-6 and TNF-α levels in vitro and in vivo”

   CellsLPS-induced RAW 264.7 cells and periodontitis mice

   Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy

   Molecules (Basel, Switzerland)·Jul 7, 2025

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1. High glucose increases TNF-α and IL-6 in human cells (cord blood-derived HSPCs).

   “increased secretion of the inflammatory cytokines TNFα and IL6”

   Cellscord blood-derived HSPCscord blood

   Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34⁺ hematopoietic stem cells from diabetic patients

   Cardiovascular diabetology·Mar 29, 2024

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1. Yoga decreases TNF-α and IL-6 in humans (combined with high-dose vitamin D (YHD group)).

   “there were significant decreases in tumor necrosis factor-α (TNF-α) and interleukin-6 levels in the Y-HVD group after the intervention”

   Human trialcombined with high-dose vitamin D (YHD group)4000 IU vitamin D12 weeks

   Serum and gene expression profile of cytokines following combination of yoga training and vitamin D supplementation in breast cancer survivors: a randomized controlled trial

   BMC women's health·Mar 24, 2022

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1. Resveratrol prevents TNF-α and IL-6 in mice (SAMP8 mice fed a high-fat diet).

   “tumor necrosis factor alpha (TNF-α) and interleukin (IL-6) were increased after HF, and resveratrol prevents its increase.”

   AnimalsSAMP8 mice fed a high-fat diet

   Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway

   Molecular neurobiology·Feb 12, 2016

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1. TNF-α and IL-6 is associated with cognitive deficits across multiple neurological disorders.

   “There is significant overlap in these cytokine and chemokine expression profiles across diseases, with TNFα and IL-6 strongly associated with cognitive deficits in multiple disorders.”

   Reviewacross multiple neurological disorders

   Immunity impacts cognitive deficits across neurological disorders

   Journal of neurochemistry·Oct 29, 2023

1. Anaerostipes and Faecalibacterium is associated with TNF-α and IL-6 in humans.

   “Anaerostipes and Faecalibacterium abundance was negatively correlated with TNF-α and IL-6 levels.”

   Humans

   Age-Related Changes in the Composition of Intestinal Microbiota in Elderly Chinese Individuals

   Gerontology·Jan 31, 2022

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1. Older age is associated with TNF-α and IL-6 in humans (elderly compared with adults).

   “Pro-inflammatory cytokines, TNF-α and IL-6, were higher in elderly people compared to adults.”

   Humanselderly compared with adultsplasma

   Effects of Ageing on the Immune System: Infants to Elderly

   Scandinavian journal of immunology·Jan 26, 2016