Telomere length change

1. Caloric restriction has no effect on telomere length change in humans.

   “No differences were observed when considering TL change across the study duration from baseline to 24-months”

   Human trialhealthy, nonobese adults2 years

   Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis

   Aging cell·Mar 19, 2024

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1. Telomere length change has no effect on change in physical abilities in humans.

   “However, change in telomere length did not predict change in cognitive or physical abilities.”

   Humans

   Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921

   Mechanisms of ageing and development·Feb 10, 2016

1. Telomere length change has no effect on change in cognitive abilities in humans.

   “However, change in telomere length did not predict change in cognitive or physical abilities.”

   Humans

   Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921

   Mechanisms of ageing and development·Feb 10, 2016

1. Early-life telomere length has no effect on telomere length change in P. domesticus.

   “Individual changes in TL were independent of early-life TL.”

   Animals

   Longitudinal telomere dynamics within natural lifespans of a wild bird

   Scientific reports·Mar 15, 2023

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1. Type 1 diabetes is associated with telomere length change in humans (shortened 55.3%, lengthened 40.0%, no change 4.7%).

   “telomeres shortened in 55.3% of subjects, lengthened in 40.0%, and did not change in 4.7%.”

   Humanstype 1 diabetesmedian 6.8 yearsn = 618

   Telomeres do not always shorten over time in individuals with type 1 diabetes

   Diabetes research and clinical practice·May 14, 2022

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