Telomere attrition rate

1. Metformin decreases telomere attrition rate in humans.

   “Compared to healthy volunteers, telomere attrition was markedly reduced in diabetic patients who were on metformin.”

   Humansin diabetic patients consuming metformin

   Metformin exhibits gender specific impact on telomere dynamics by enhancing RAP1 expression in type-2 diabetes mellitus

   Acta diabetologica·9 Feb 2026

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1. Sex has no effect on telomere attrition rate in M. molossus.

   “No evidence was found for sex-specific rates of telomere attrition.”

   Animalsmulti-year317 females, 175 malessn = 492

   Defying expectations: Extended lifespan and limited age-related telomere shortening in the tropical bat species, Molossus molossus

   bioRxiv (Cold Spring Harbor Laboratory)·31 Oct 2025Preprint

1. Metabolic cardio-respiratory rate is associated with telomere attrition rate in silico (PGLS slope 0.36 (95% CI 0.26–0.46)).

   “telomere attrition rate δ ∝ MCR0·36 (PGLS slope 0.36, 95% CI 0.26–0.46, R2 = 0.58, p < 0.001) across 25 mammalian and avian species”

   In silicon = 25

   Within-Species Validation of the MCR–Lifespan Scaling Exponent: Evidence from 15 Rat Species/Strains, with Mechanistic and Telomere-Based Derivations

   Preprint·10 Jun 2026

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