Metabolic cardio-respiratory rate

1. Metabolic cardio-respiratory rate is associated with telomere attrition rate in silico (PGLS slope 0.36 (95% CI 0.26–0.46)).

   “telomere attrition rate δ ∝ MCR0·36 (PGLS slope 0.36, 95% CI 0.26–0.46, R2 = 0.58, p < 0.001) across 25 mammalian and avian species”

   In silicon = 25

   Within-Species Validation of the MCR–Lifespan Scaling Exponent: Evidence from 15 Rat Species/Strains, with Mechanistic and Telomere-Based Derivations

   Preprint·10 Jun 2026

More on Telomere attrition rate

1. Metabolic cardio-respiratory rate is associated with lifespan in silico (slope -0.360 (95% CI -0.48 to -0.24)).

   “Ordinary least squares regression on the 15 data points yielded a slope of −0.360 (95% CI: −0.48 to −0.24, R2 = 0.62, p < 0.001).”

   In silico

   Within-Species Validation of the MCR–Lifespan Scaling Exponent: Evidence from 15 Rat Species/Strains, with Mechanistic and Telomere-Based Derivations

   Preprint·10 Jun 2026