Telomerase subunit expression

There are 2 papers on telomerase subunit expression in aging research: 2 observational studies in people.

Biomarker

2 papers study it2 findings

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  • Humans2

Interventions

2

Reproductive age

no changein humans1

1 study
  1. Reproductive age was not clearly linked with telomerase subunit expression in humans (no significant difference by age or follicle size).

    “Telomerase subunit expression was detected in preantral follicles without any significant age or size differences.”

    Humansno significant difference by age or follicle sizepreantral folliclesfemales

    Age-related changes in mitochondrial markers and telomere dynamics during initial growth of human preantral follicles

    Journal of assisted reproduction and genetics

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Estradiol

upin human cells1

1 study
  1. Estradiol increases telomerase subunit expression in human cells (Ex vivo exposure; preferential response in male-derived cells).

    “telomerase subunits were preferentially upregulated in male-derived bone marrow MNCs exposed ex vivo to estradiol as compared with female MNCs.”

    CellsEx vivo exposure; preferential response in male-derived cellsBone marrow mononuclear cellsMale versus females

    Influence of Donor and Recipient Gender on Telomere Maintenance after Umbilical Cord Blood Cell Transplantation: A Study by the Gruppo Italiano Trapianto Di Midollo Osseo

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

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