TCF7 regulatory role

Older age is associated with TCF7 regulatory role in humans.

“Enhancer-based gene regulatory network analyses identified a reduced role of TCF7 and increased activity of inflammatory regulators, including FOSL2, in aged T cells.”

Humanshealthy donorsT cell

Multimodal single-cell analysis uncovers transcription factor networks underlying T-cell aging

bioRxiv (Cold Spring Harbor Laboratory)·21 May 2026Preprint