Differentiated memory and effector T-cell abundance

Older age is associated with differentiated memory and effector T-cell abundance in humans.

“we detected pronounced age-associated changes in T cells, including loss of naïve CD8+ T cells and expansion of differentiated memory and effector populations.”

Humanshealthy donorsperipheral blood mononuclear cells

Multimodal single-cell analysis uncovers transcription factor networks underlying T-cell aging

bioRxiv (Cold Spring Harbor Laboratory)·21 May 2026Preprint