sTREM2
7 papers12 findings
- Humans7
Effects
2Aβ-PET centiloid
mediatesin humans1downin humans1
1 study
Aβ-PET centiloid
mediatesin humans1downin humans1
sTREM2 mediates Aβ-PET centiloid in humans (attenuation by 27%).
“attenuating the relationship between p ‐tau 231 and Aβ‐PET accumulation by 27%”
Humansmediates association between p-tau231 and Aβ-PET accumulationbrain
AAIC 2025 abstractDec 23, 2025
sTREM2 decreases Aβ-PET centiloid in humans (β -1.67 (95% CI -2.83 to -0.51), p < 0.01).
“Notably, higher sTREM2 was associated with reduced rates of Aβ accumulation (β [95% CI]: ‐1.67 [‐2.83 to ‐0.51], p <0.01)”
Humansbrain
AAIC 2025 abstractDec 23, 2025
Cognitive function
mediatesin humans1
1 study
Cognitive function
mediatesin humans1
sTREM2 mediates cognitive function in humans.
“CSF sTREM2 fully mediated the link between older brain-age and cognitive decline in ALFA+”
Humansin ALFA+ cohort
Molecular psychiatryApr 12, 2025
Upstream
1P-TAU231
upin humans1
1 study
P-TAU231
upin humans1
P-TAU231 increases sTREM2 in humans (β 0.18 (95% CI 0.11–0.25), p < 0.001).
“Elevated p ‐tau 231 was also linked to increased CSF sTREM2 (β [95% CI]: 0.18 [0.11–0.25], p <0.001).”
Humansbrain
AAIC 2025 abstractDec 23, 2025
Associations
7Neurogranin
downin humans1
1 study
Neurogranin
downin humans1
sTREM2 is associated with neurogranin in humans (β = -0.01, p = 0.03 for WRAP; β = -0.01, p = 0.04 in ALFA+).
“higher baseline sTREM2 was associated with a smaller longitudinal increase in neurogranin in both cohorts (β = -0.01, p = 0.03 for WRAP, β = -0.01, p = 0.04 in ALFA+)”
Humanscerebrospinal fluid
Molecular neurodegenerationOct 17, 2025
Neurogranin predicts sTREM2 in humans (β = -0.02, p = 0.006).
“lower baseline neurogranin and α-synuclein and higher S100B predicted greater increases in sTREM2 over time independently of AD-related markers in the WRAP cohort (β = -0.02, p = 0.006”
Humanscerebrospinal fluid
Molecular neurodegenerationOct 17, 2025
Aβ accumulation
downin humans1
1 study
Aβ accumulation
downin humans1
sTREM2 is associated with Aβ accumulation in humans (β -1.67, 95% CI -2.83 to -0.51, p<0.01).
“higher sTREM2 was associated with reduced rates of Aβ accumulation (β [95% CI]: ‐1.67 [‐2.83 to ‐0.51], p <0.01)”
Humanscognitively unimpaired individuals3.4 yearsn = 187
AAIC 2025 abstractDec 24, 2025
P-TAU231
upin humans1
1 study
P-TAU231
upin humans1
P-TAU231 is associated with sTREM2 in humans (β 0.18, 95% CI 0.11–0.25, p<0.001).
“Elevated p ‐tau 231 was also linked to increased CSF sTREM2 (β [95% CI]: 0.18 [0.11–0.25], p <0.001).”
Humanscognitively unimpaired individuals3.4 yearsn = 187
AAIC 2025 abstractDec 24, 2025
S100B
upin humans1
1 study
S100B
upin humans1
S100B predicts sTREM2 in humans (β = 0.02, p = 0.03).
“higher S100B predicted greater increases in sTREM2 over time independently of AD-related markers in the WRAP cohort (β = -0.02, p = 0.006; β = -0.02, p = 0.01; β = 0.02, p = 0.03”
Humanscerebrospinal fluid
Molecular neurodegenerationOct 17, 2025
α-synuclein
downin humans1
1 study
α-synuclein
downin humans1
α-synuclein predicts sTREM2 in humans (β = -0.02, p = 0.01).
“α-synuclein and higher S100B predicted greater increases in sTREM2 over time independently of AD-related markers in the WRAP cohort (β = -0.02, p = 0.006; β = -0.02, p = 0.01”
Humanscerebrospinal fluid
Molecular neurodegenerationOct 17, 2025
Brain age delta
downin humans1
1 study
Brain age delta
downin humans1
sTREM2 is associated with brain age delta in humans.
“higher CSF sTREM2 was associated with a younger brain-age after adjusting for AD pathology”
Humansadjusted for AD pathology
Molecular psychiatryApr 12, 2025
Female sex
upin humans1
1 study
Female sex
upin humans1
Female sex is associated with sTREM2 in humans (β = 0.146, P = 0.002).
“among the APOE ε4 allele carriers, women exhibited significantly higher sTREM2 levels than men (β = 0.146, P = 0.002).”
Humansin APOE ε4 allele carrierscerebrospinal fluid
The longitudinal trajectory of CSF sTREM2: the alzheimer's disease neuroimaging initiative
Alzheimer's research & therapyJun 26, 2024