Papers on SQSTM1

46 papers1 new in 30 days

Friday, October 30

Journal of Alzheimer's DiseaseOct 30

Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia

Cohort study of 557 peopleSQSTM1

Wednesday, October 7

TheriogenologyOct 7

A protein helped egg cells from aged cattle mature in the lab

In laboratory experiments, injecting instructions for making a protein reduced maturation failure in aged cattle egg cells and restored the function of their…In laboratory experiments, injecting instructions for making a protein reduced maturation failure in aged cattle egg cells and restored the function of their energy-producing structures.

Figure from Theriogenology

Experiments in cellsInterventions

Thursday, August 6

Antioxidants & Redox SignalingAug 6

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Experiments in miceBlood and immune system

Saturday, May 30

NeurotoxicologyMay 30

The association between exposure to flame retardants and cognitive function in the elderly: Unveiling potential intervention strategies

Cross-sectional study in peoplePopulations

Tuesday, May 19

The International Journal of Cardiovascular ImagingMay 19

Age-related changes in lysosomal abundance in mouse hearts assessed by Lysotracker fluorescence imaging and autophagy gene expression analysis

Experiments in animalsBiomarkers

Tuesday, February 17

bioRxivFeb 17

Lysosomal abundance in young and aged mouse hearts assessed by In Vivo Imaging Systems (IVIS) Lysotracker imaging and autophagy-related gene expression

Preprint: experiments in animalsAutophagy

Sunday, February 15

PhytomedicineFeb 15

Stress endurance mediates the healthspan-promoting effect of two newly described iridoid glycosides from Verbascum nigrum ssp. abietinum in Caenorhabditis elegans

Experiments in wormsInterventions

Tuesday, January 13

EMBO Molecular MedicineJan 13

Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins

Experiments in ratsInterventions

Tuesday, December 30

Aging CellDec 30

Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype

Experiments in miceSenescence-associated secretory phenotype (SASP)

Thursday, December 25

BMC Musculoskeletal DisordersDec 25

Identification and validation of ferroptosis-related key hub genes linking hypoxia and osteoporosis

Experiments in ratsHypoxia and HIF signaling

Sunday, November 2

The International Journal of Biochemistry & Cell BiologyNov 2

The role of autophagy in intervertebral disc degeneration and the regulation mechanism of AP-2α on autophagy

Experiments in ratsAutophagy

Friday, October 31

Frontiers in AgingOct 31

Exploring the involvement of ferroptosis-associated genes and pathways in mesenchymal stem cell aging through bioinformatics analysis

Experiments in cellsFerroptosis

Sunday, October 19

Tissue & CellOct 19

Atorvastatin ameliorates cerebral cortical pathological and cognitive alterations in aged rats: Histological & immunohistochemical study

Experiments in 24 ratsAtorvastatin

Thursday, October 2

AutophagyOct 2

Aging-rewired metabolic cues promote autophagy and senescence via DRAM1

Experiments in miceAutophagy

Monday, September 1

Journal of Alzheimer's DiseaseSep 1

Role of Ruminococcus gnavus in the elderly with cognitive impairment: A case-control study and an animal experiment

Experiments in miceMechanisms

Thursday, August 14

Neural Regeneration ResearchAug 14

Retrograde axonal transport of autophagic vesicles and dynein-dynactin protein interaction are attenuated during aging in the rat optic nerve in vivo

Experiments in ratsAutophagy

Tuesday, March 4

AutophagyMar 4

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration

Experiments in human cellsAutophagy

Thursday, December 26

Problemy Radiatsiinoi Medytsyny Ta RadiobiolohiiDec 26

DYSREGULATION OF AUTOPHAGY IN PERIPHERAL BLOOD LEUCOCYTES IS A FACTOR IN THE DEVELOPMENT OF INFLAMMAGING IN IMMUNOCOMPROMISED PERSONS ON THE EXAMPLE OF THE SERVICEMEN OF THE DEFENSE FORCES OF UKRAINE AND CLEAN-UP WORKERS OF THE CHORNOBYL ACCIDENT

Cross-sectional study of 103 peopleAutophagy

Tuesday, October 15

AutophagyOct 15

Mitophagy as a guardian against cellular aging

ReviewMitophagy

Thursday, October 10

Molecular NeurodegenerationOct 10

Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease

Cohort study of 113 peoplePreclinical Alzheimer's disease

Monday, September 2

Biochemistry BiokhimiiaSep 2

Differences in the Effect of Beta-Hydroxybutyrate on the Mitochondrial Biogenesis, Oxidative Stress and Inflammation Markers in Tissues from Young and Old Rats

Experiments in ratsInterventions

Thursday, June 27

Cell ReportsJun 27

BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion

Experiments in mouse cellsFerroptosis

Monday, February 19

Autophagy ReportsFeb 19

Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells

Study in peopleAutophagy

Thursday, January 11

The EMBO JournalJan 11

Control of NAD⁺ homeostasis by autophagic flux modulates mitochondrial and cardiac function

Experiments in animalsAutophagy

Tuesday, August 15

Cell Reports MedicineAug 15

Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects

Trial in peoplePsoriasis

Monday, March 13

Frontiers in Cell and Developmental BiologyMar 13

Determination of the autophagic flux in murine and human peripheral blood mononuclear cells

Experiments in mouse cellsAutophagy

Friday, November 25

Current Issues in Molecular BiologyNov 25

Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration

Computational studyMechanisms

Wednesday, October 12

Frontiers in GastroenterologyOct 12

Effect of calorie-restriction and rapamycin on autophagy and the severity of caerulein-induced experimental acute pancreatitis in mice

Experiments in miceDietary restriction

Wednesday, August 10

AutophagyAug 10

Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity

Experiments in wormsAutophagy

Sunday, April 24

LifeApr 24

P62/SQSTM1 beyond Autophagy: Physiological Role and Therapeutic Applications in Laboratory and Domestic Animals

ReviewInterventions