SIRT1 promoter chromatin accessibility

1 paper1 finding

Human trial1

Interventions

1

Metformin

upin humans1

1 study

Metformin increases SIRT1 promoter chromatin accessibility in humans.
“increased SIRT1 gene/protein expression and SIRT1 promoter chromatin accessibility”
Human trialprediabetes; comparison with baselineperipheral blood mononuclear cells1500 mg/day2 monthsn = 38
Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial
Nutrition, metabolism, and cardiovascular diseases : NMCD24 Mar 2015

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Nutrition, Metabolism, and Cardiovascular Diseases24 Mar

Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

Randomised trial in 38 peopleMetformin