Senescent microglia

3 papers1 finding

Animals3

Interventions

1

Senolytics

downin mice1

1 study

Senolytics decrease senescent microglia in mice.
“senolytic treatment reduces senescent microglia burden and attenuates disease severity in an age- and drug-dependent manner”
Animalsin experimental autoimmune encephalomyelitis
Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach
Frontiers in immunology7 Oct 2025

More on Senolytics

Latest

9 in 12 months

Cells24 Sep

Border-Associated Macrophage Migrasomes in Alzheimer's Disease: An Emerging Aβ-Senescence-Microglia Axis?

ReviewCellular senescence

Ageing Research Reviews6 Sep

Mitochondria-endoplasmic reticulum contact sites (MERCS/MAM): Multi-layered upstream regulators of microglial senescence in Alzheimer's disease

ReviewCellular senescence

Neuron11 Aug

Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction

Experiments in miceTelomerase and telomere maintenance

Ageing Research Reviews26 Mar

Cellular senescence in neurodegenerative diseases: A bibliometric analysis and mechanistic synthesis linking translational pathways to therapeutic implications

Systematic reviewCellular senescence

Molecular and Cellular Neurosciences27 Feb

Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's disease - Mechanisms and therapeutic frontiers

ReviewMicrobiome composition

Advanced Science16 Feb

Dual-Target ROS-Driven Spatiotemporal Senolysis for Vascular Repair and Immune Microenvironment Reprogramming in the Treatment of Ocular Fundus Neovascularization

Experiments in miceInterventions

CNS Neuroscience & Therapeutics27 Jan

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis

ReviewMechanisms

Acta Pharmacologica Sinica1 Jan

NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway

Experiments in miceDNA damage response

AAIC 2025 Abstract24 Dec

Cadmium exposure accelerates cognitive deficits and Alzheimer's disease progression in 5xFAD mice

Experiments in miceMechanisms

Frontiers in Immunology23 Oct

Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach

Experiments in miceMultiple sclerosis