INTERLEUKIN-15 + thymosin alpha 1

Intervention

1 paper4 findings

  • 1 lab
  • Animals1

Outcomes

4

PI3K–AKT signalling

downin mice1

1 study
  1. INTERLEUKIN-15 + thymosin alpha 1 inhibits PI3K–AKT signalling in mice.

    “combination attenuated chronically overactivated phosphatidylinositol 3-kinase/protein kinase B signaling in hepatic CD8+ T cells.”

    Animalsorthotopic HCC modelcombination therapyhepatic CD8+ T cells

    IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8⁺ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

    Journal of gastroenterology and hepatology26 Mar 2026

More on PI3K–AKT signalling

Senescent CD8+ T cells

downin mice1

1 study
  1. INTERLEUKIN-15 + thymosin alpha 1 decreases senescent CD8+ T cells in mice.

    “It reduced the proportion of senescent CD8+ T cells while expanding activated effector populations”

    Animalsorthotopic HCC modelcombination therapyliver

    IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8⁺ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

    Journal of gastroenterology and hepatology26 Mar 2026

More on Senescent CD8+ T cells

Survival

upin mice1

1 study
  1. INTERLEUKIN-15 + thymosin alpha 1 extends lifespan survival in mice.

    “The combination therapy significantly suppressed tumor growth and prolonged survival.”

    Animalsorthotopic HCC modelcombination therapy

    IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8⁺ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

    Journal of gastroenterology and hepatology26 Mar 2026

Tumor growth

downin mice1

1 study
  1. INTERLEUKIN-15 + thymosin alpha 1 decreases tumor growth in mice.

    “The combination therapy significantly suppressed tumor growth and prolonged survival.”

    Animalsorthotopic HCC modelcombination therapy

    IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8⁺ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

    Journal of gastroenterology and hepatology26 Mar 2026

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