Immune-mediated inflammatory disease

1. Immune-mediated inflammatory disease increases myocardial infarction in humans (12.9 vs. 8.6 per 1000 person-years).

   “greater incidence of MI/revascularization (12.9 vs. 8.6 per 1000 person-years) than matched controls (n = 2190)”

   Humanscompared to matched controlsn = 1,095

   Spatial- and attenuation-based epicardial adipose tissue features on CT calcium-score exams predict ASCVD events in immune-mediated inflammatory diseases

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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1. Immune-mediated inflammatory disease increases epicardial adipose tissue volume in humans (p<0.005).

   “IMID patients (N=1095, SLE: 162, RA: 557, Psoriasis: 430) had significantly higher EAT volume (p<0.005)”

   Humanscompared to matched controlsn = 1,095

   Spatial- and attenuation-based epicardial adipose tissue features on CT calcium-score exams predict ASCVD events in immune-mediated inflammatory diseases

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Epicardial adipose tissue volume

1. Immune-mediated inflammatory disease increases senescent CD8+ T cells in humans.

   “T8sen, but not T4sen, accumulated more in patients with IMIDs than in patients with lung cancer and healthy donors.”

   Humansin IMID patients compared to lung cancer patients and healthy donors

   Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines

   Clinical and experimental immunology·21 Jan 2025

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1. Immune-mediated inflammatory disease raises the risk of incident myocardial infarction or coronary revascularization in humans (six-fold higher (7.13 vs 1.12 per 1000 person-years)).

   “Among patients with no coronary calcium, IMID patients experienced a six-fold higher event rate than controls (7.13 vs 1.12 per 1000 person-years).”

   Humansin patients with zero CAC

   Coronary Artery Calcium and Risk of Cardiovascular Events in Immune-Mediated Inflammatory Disease from the CLARIFY No/Low-Cost CT Calcium Score Registry

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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