4 papers3 findings
Dydrogesterone
no changein human cells1
Dydrogesterone has no effect on senescence marker expression in human cells.
“neither treatment significantly reduced DIO2 or β-GAL expression.”
CellsCells from women with recurrent pregnancy loss; DIO2 and β-GAL readoutsdecidual cellfemales
Decidual senescence in recurrent pregnancy loss: forkhead box M1-targeted progesterone treatment
Reproductive biomedicine online28 Feb 2026
Medroxyprogesterone acetate
no changein human cells1
Medroxyprogesterone acetate has no effect on senescence marker expression in human cells.
“neither treatment significantly reduced DIO2 or β-GAL expression.”
CellsCells from women with recurrent pregnancy loss; DIO2 and β-GAL readoutsdecidual cellfemales
Decidual senescence in recurrent pregnancy loss: forkhead box M1-targeted progesterone treatment
Reproductive biomedicine online28 Feb 2026
G2 cell-cycle arrest
upin human cells1
G2 cell-cycle arrest is associated with senescence marker expression in human cells.
“We found that G2-arrested senescent cells feature higher senescence marker expression than G1-arrested senescent cells.”
CellsG2-arrested versus G1-arrested senescent cellsprimary human endothelial cells and fibroblasts
Aging7 Aug 2025
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.