What does the research say about senescence-associated secretory factors?

Senescence-associated secretory factors

There are 3 papers on senescence-associated secretory factors in aging research: 1 trial in people, 1 in animals, 1 in cells. The newest story, Oct 29, 2026: “Early drug dosing prevents pain-related behavior in mice”.

Biomarker

3 papers study it10 more mention it1 finding

1 new paper in 30 daysSee all 13 papers on senescence-associated secretory factors

Human trial1
Animals1
Cells1

Interventions

Palbociclib

upin human cells1

1 study

Palbociclib increases senescence-associated secretory factors in human cells (significant; P < 0.01).
“the mRNA expression levels of senescence-related secretory factors also increased significantly in HK-2 cells after palbociclib treatment (P < 0.01).”
Cells5 days
Palbociclib induces cell cycle arrest and senescence of human renal tubular epithelial cells in vitro
Nan fang yi ke da xue xue bao = Journal of Southern Medical UniversityDec 30, 2020

Funding

1 grant since 2025

Japan Society for the Promotion of Science¥4.7M

Identification of cellular senescence-associated secretory factors and elucidation of their production mechanisms in rheumatoid arthritis-associated interstitial pneumonia
Japan Society for the Promotion of ScienceToho University¥4.7M2025–2028

Latest

5 papers in 12 months

Advanced ScienceMay 25

Early drug dosing prevents pain-related behavior in mice

Weekly dosing for five months also preserved spinal disc volume and bone structure in mice prone to early spine degeneration.Weekly dosing for five months also preserved spinal disc volume and bone structure in mice prone to early spine degeneration.

Mouse studyInterventions

Paper

Research SquareMar 18

Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer's Disease

Preprint: non-randomized trial in peopleSenolytics

Paper

Nan Fang Yi Ke Da Xue Xue BaoJan 1

Palbociclib induces cell cycle arrest and senescence of human renal tubular epithelial cells in vitro

Experiments in human cellsCell cycle regulation

Paper

Frontiers in EndocrinologyOct 29

The aging secretome as a candidate driver of bone remodeling imbalance: myokines, adipokines, and senescence-associated secretory factors

ReviewCellular senescence

Paper

Advanced ScienceSep 30

Long-term human skin platform models chronic inflammation and senolytic treatments

The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after prolonged exposure.The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after prolonged exposure.

Experiments in human cellsInflammation

Paper

bioRxivAug 20