Senescence-associated marker expression

1. Substrate stiffness increases senescence-associated marker expression in human cells.

   “increasing substrate stiffness enhanced fibroblast spreading, stress fiber thickening, focal adhesion maturation, cellular stiffness, and senescence-associated marker expression.”

   Cellsincreasing substrate stiffnesstunable polyacrylamide hydrogelsfibroblast

   SERPINE1–AP2A1 interplay links substrate stiffness to fibroblast senescence

   bioRxiv (Cold Spring Harbor Laboratory)·1 Jul 2026Preprint

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1. Etoposide has no effect on senescence-associated marker expression in mouse cells.

   “While DNA damage increased after treatment, after 24 h, no change in the expression of senescence-associated markers was observed.”

   CellsEtoposide-induced DNA damageprimary neuron24 h

   DNA Damage and Senescence in the Aging and Alzheimer's Disease Cortex Are Not Uniformly Distributed

   Biomedicines·14 Jun 2024

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