There are 2 papers on robustness in aging research: 1 observational study in people. The newest story, Nov 2, 2026: “Shielded iron storage helps cells resist a form of death”.
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“robustness showed significant inverse associations with most outcomes (3-year follow-up: OR (95%CI): disability 0.448 (0.300-0.668)”
Longitudinal lesion segmentation algorithm
upin silico1
longitudinal lesion segmentation algorithm increases robustness in silico (clinical data).
“applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods”
In silicoclinical data
Longitudinal segmentation of age-related white matter hyperintensities
Medical image analysis
Mortality
downin humans1
Robustness is linked with a lower risk of mortality in humans (0.649 (95%CI 0.460-0.915)).
“and all-cause mortality 0.649 (0.460-0.915)”
Humans7-year follow-upn = 940
The journal of nutrition, health & aging
Hospitalization
downin humans1OR 0.547
Robustness is linked with a lower risk of hospitalization in humans (OR 0.547 (95%CI 0.349-0.856)).
“hospitalization 0.547 (0.349-0.856)”
Humans7-year follow-upn = 940
The journal of nutrition, health & aging
Falls
downin humans1OR 0.477
Robustness is linked with a lower risk of falls in humans (OR 0.477 (95%CI 0.298-0.764)).
“7-year follow-up: falls 0.477 (0.298-0.764)”
Humans7-year follow-upn = 940
The journal of nutrition, health & aging
Disability
downin humans1OR 0.448
Robustness is linked with a lower risk of disability in humans (OR 0.448 (95%CI 0.300-0.668)).
“robustness showed significant inverse associations with most outcomes (3-year follow-up: OR (95%CI): disability 0.448 (0.300-0.668)”
Humans3-year follow-upn = 940
The journal of nutrition, health & aging
Japan Society for the Promotion of Science¥13.7MNational Institute on Aging$1.6MNational Institute of Arthritis and Musculoskeletal and Skin Diseases$476K
Japan Society for the Promotion of ScienceNational Institute of Technology, Suzuka College¥4.6M2026–2029
Japan Society for the Promotion of ScienceUniversity of the Ryukyus¥4.6M2025–2028
Japan Society for the Promotion of ScienceShowa University¥4.6M2025–2028
National Institute on AgingColumbia University Health Sciences$512K2020–2025
Bone Robustness as a Biomarker of Skeletal Aging and Fragility
National Institute of Arthritis and Musculoskeletal and Skin DiseasesUniversity of Michigan at Ann Arbor$476K2014–2020
Cell experiments linked protected iron storage to senescence, a state in which cells stop dividing, and resistance to iron-dependent cell death.Cell experiments linked protected iron storage to senescence, a state in which cells stop dividing, and resistance to iron-dependent cell death.
Trained in a European cohort and tested in three others, the model estimated lifespan trajectories associated with observed mortality outcomes.Trained in a European cohort and tested in three others, the model estimated lifespan trajectories associated with observed mortality outcomes.