Medical Image Analysis · Feb 24, 2017

Longitudinal segmentation of age-related white matter hyperintensities

By Sudre CH, Cardoso MJ, Ourselin S et al.

Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For evaluation purposes, a longitudinal lesion simulator is created allowing for the comparison between the longitudinal and the cross-sectional version in various situations of lesion load progression. Finally, applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods and findings are aligned with previously reported clinical patterns.

doi.org/10.1016/j.media.2017.02.007Open accessPubMed 28282640Biomarkers