Replication stress

There are 3 papers on replication stress in aging research: none in people yet, 1 in animals, 2 in cells. The newest story, Nov 2, 2026: “DNA repair protein deficiency triggers DNA leakage in human cells”.

Biomarker

3 papers study it167 more mention it1 finding

See all 170 papers on replication stress

  • Animals1
  • Cells2

Upstream

1

MIR-181A

downin mice1

1 study
  1. MIR-181A decreases replication stress in mice (shown by deficiency in murine T cells).

    “miR-181ab1-deficient murine T cells develop excessive replication stress after activation”

    Animalsshown by deficiency in murine T cellsT cell

    Histone deficiency and accelerated replication stress in T cell aging

    The Journal of clinical investigation

More on MIR-181A

Funding

3 grants since 2018

National Institute on Aging$1.7MNational Institute of General Medical Sciences$973KNational Heart, Lung, and Blood Institute$92.8K

Latest

Dec 2025: 1Jan 2026: 6Feb 2026: 1Mar 2026: 1Apr 2026: 3May 2026: 1Jun 2026: 5Jul 2026: 2Aug 2026: 1Sep 2026: 2Oct 2026: 0Nov 2026: 023 papers in 12 months
Redox Biology

DNA repair protein deficiency triggers DNA leakage in human cells

DNA fragments outside the nucleus appeared in 11.8% of breast cells deficient in the repair protein, compared with 2.2% of controls under normal conditions.DNA fragments outside the nucleus appeared in 11.8% of breast cells deficient in the repair protein, compared with 2.2% of controls under normal conditions.

Human cell studyDNA repair

See all 170 papers on replication stress