There are 5 papers on MIR-181A in aging research: none in people yet, 4 in animals, 1 review.
5 papers study it6 findings
At a glance
The findings reach mice, none yet in people. 3 independent labs in 3 countries.
None of its findings points the other way.
- 3 independent labs in 3 countries
- Funders: Emory University and others
- Animals4
Effects
4Replication stress
downin mice1
1 study
Replication stress
downin mice1
MIR-181A decreases replication stress in mice (shown by deficiency in murine T cells).
“miR-181ab1-deficient murine T cells develop excessive replication stress after activation”
Animalsshown by deficiency in murine T cellsT cell
Histone deficiency and accelerated replication stress in T cell aging
The Journal of clinical investigation
Antigen-specific CD4 T cell expansion
downin mice1
1 study
Antigen-specific CD4 T cell expansion
downin mice1
MIR-181A decreases antigen-specific CD4 T cell expansion in mice (T cell-specific miR-181ab1 knockout during LCMV infection, compared with wild-type mice).
“Antigen-specific CD4 T cells in mice with miR-181a-deficient T cells expand more and have a broader TCR repertoire with preferential expansion of high-affinity T cells than in wild-type mice.”
AnimalsT cell-specific miR-181ab1 knockout during LCMV infection, compared with wild-type mice
Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency
Cell reports
Generation of antigen-specific CD8 effector T cells
upin mice1
1 study
Generation of antigen-specific CD8 effector T cells
upin mice1
MIR-181A increases generation of antigen-specific CD8 effector T cells in mice (T cell-specific miR-181ab1 knockout during LCMV infection).
“generation of antigen-specific miR-181a-deficient CD8 effector T cells is particularly impaired”
AnimalsT cell-specific miR-181ab1 knockout during LCMV infection
Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency
Cell reports
Viral clearance
upin mice1
1 study
Viral clearance
upin mice1
MIR-181A increases viral clearance in mice (T cell-specific miR-181ab1 knockout during LCMV infection).
“We found that miR-181a deficiency delays viral clearance, thereby biasing the immune response in favor of CD4 over CD8 T cells.”
AnimalsT cell-specific miR-181ab1 knockout during LCMV infection
Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency
Cell reports
Upstream
1Age
upin rats1
1 study
Age
upin rats1
Age increases MIR-181A in rats.
“miRNA-181a expression was significantly increased as a function of age”
Animalslivermales
Experimental gerontology
Associations
1SIRT1 expression
mixedin mice1
1 study
SIRT1 expression
mixedin mice1
MIR-181A is associated with SIRT1 expression in mice.
“We identified miR-181a as a regulator of the sirtuin1 (Sirt1) gene expression in skeletal muscle”
Animalsskeletal muscle
The functional consequences of age-related changes in microRNA expression in skeletal muscle
Biogerontology