Pulsatile growth hormone secretion

1. Growth hormone-releasing peptide-2 increases pulsatile growth hormone secretion in humans (P < 0.001).

   “Submaximally stimulated pulsatile GH secretion was positively determined by PRE vs. POST age (P < 0.001), E(2) repletion vs. depletion (P = 0.001) and GHRP-2 vs. GHRH stimulation (P < 0.001)”

   Human trialcompared with GHRH stimulation at a half-maximally stimulatory dose, after adjustment for abdominal visceral fat and basal secretion0.33 mug/kgfemales

   Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp

   The Journal of clinical endocrinology and metabolism·Oct 26, 2009

2. Growth hormone-releasing peptide-2 increases pulsatile growth hormone secretion in humans (compared with GHRH, independent of age; during low and high estradiol) (more stimulatory than GHRH; P = 0.011 (low E(2)), P < 0.001 (high E(2))).

   “Independently of age, GHRP-2 was more stimulatory than GHRH during low E(2) (P = 0.011) and high E(2) (P < 0.001).”

   Human trialcompared with GHRH, independent of age; during low and high estradiolfemales

   Relative effects of estrogen, age, and visceral fat on pulsatile growth hormone secretion in healthy women

   American journal of physiology. Endocrinology and metabolism·May 26, 2009

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1. 17-alpha-estradiol showed no clear effect on pulsatile growth hormone secretion in mice.

   “without inducing any changes in pulsatile growth hormone (GH) secretion”

   Animalsmales

   17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner

   The journals of gerontology. Series A, Biological sciences and medical sciences·Aug 29, 2020

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1. Estradiol increases pulsatile growth hormone secretion in humans (P = 0.001).

   “Submaximally stimulated pulsatile GH secretion was positively determined by PRE vs. POST age (P < 0.001), E(2) repletion vs. depletion (P = 0.001) and GHRP-2 vs. GHRH stimulation (P < 0.001)”

   Human trialestradiol repletion vs depletion under gonadal-axis down-regulation with leuprolide, after adjustment for abdominal visceral fat and basal secretiontransdermalfemales

   Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp

   The Journal of clinical endocrinology and metabolism·Oct 26, 2009

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1. Menopausal status decreases pulsatile growth hormone secretion in humans (independent of estradiol status; in response to GHRH and GHRP-2) (P = 0.028 (GHRH); P < 0.001 (GHRP-2)).

   “Independently of E(2) status, POST women had lower GH responses to both GHRH (P = 0.028) and GHRP-2 (P < 0.001) than PRE women.”

   Human trialindependent of estradiol status; in response to GHRH and GHRP-2females

   Relative effects of estrogen, age, and visceral fat on pulsatile growth hormone secretion in healthy women

   American journal of physiology. Endocrinology and metabolism·May 26, 2009

More on Menopausal status

1. Testosterone increases pulsatile growth hormone secretion in humans.

   “stimulated pulsatile GH secretion (frequency P = 0.037, mass per burst P = 0.038)”

   Human trialmalesn = 24

   Testosterone supplementation in older men restrains insulin-like growth factor's dose-dependent feedback inhibition of pulsatile growth hormone secretion

   The Journal of clinical endocrinology and metabolism·Nov 4, 2008

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1. Insulin-like growth factor 1 decreases pulsatile growth hormone secretion in humans (exogenous recombinant IGF-I injection).

   “suppressed pulsatile GH secretion (P = 0.003), burst mass (P = 0.025), burst number (P = 0.005)”

   Human trialexogenous recombinant IGF-I injectionrecombinant humanmalesn = 24

   Testosterone supplementation in older men restrains insulin-like growth factor's dose-dependent feedback inhibition of pulsatile growth hormone secretion

   The Journal of clinical endocrinology and metabolism·Nov 4, 2008

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1. Premenopausal vs postmenopausal age increases pulsatile growth hormone secretion in humans (P < 0.001).

   “Submaximally stimulated pulsatile GH secretion was positively determined by PRE vs. POST age (P < 0.001), E(2) repletion vs. depletion (P = 0.001) and GHRP-2 vs. GHRH stimulation (P < 0.001)”

   Human trialsubmaximal GHRP-2 or GHRH stimulation, after adjustment for abdominal visceral fat and basal secretionfemales

   Pre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp

   The Journal of clinical endocrinology and metabolism·Oct 26, 2009

1. Aged animals decrease pulsatile growth hormone secretion.

   “the mean amounts of GH released over 24 h, and the response of GH to the administration of GH-releasing hormone (GHRH) are lower than in young adults”

   Review

   Aspects of the neuroendocrine control of growth hormone secretion in ageing mammals

   Journal of reproduction and fertility. Supplement·Jan 1, 1993

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