Growth hormone-releasing hormone
Growth hormone-releasing hormone has been studied in 7 papers since 1986: 3 trials in people, 1 in animals, 1 in cells, 2 reviews. The newest paper, Jul 11, 2025: “The Role of Growth Hormone-Releasing Hormone and the Hypothalamic-Pituitary-Somatotropic Axis in Aging: Potential Therapeutic Applications and Risks”.
“In E the GH response to 3 micrograms/kg HEX or GHRH were clearly higher than those to 2 micrograms/kg.”
None of its findings points the other way.
- 3 independent labs in 1 country
- Funder: National Institute of Diabetes and Digestive and Kidney Diseases
- Human trial3
- Animals1
- Cells1
What did studies of Growth hormone-releasing hormone find?
10Studies of Growth hormone-releasing hormone measured 10 outcomes; the most studied are cognitive function (1 study), muscle strength (1) and somatotrope proliferation (1).
Cognitive function
upin reviews1
1 study
Cognitive function
upin reviews1
Growth hormone-releasing hormone improves cognitive function.
“studies suggest that GHRH-based therapies can improve body composition, muscle strength, cognitive function, and cardiovascular health”
Review
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Muscle strength
upin reviews1
1 study
Muscle strength
upin reviews1
Growth hormone-releasing hormone improves muscle strength.
“studies suggest that GHRH-based therapies can improve body composition, muscle strength, cognitive function, and cardiovascular health”
Review
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Somatotrope proliferation
upin reviews1
1 study
Somatotrope proliferation
upin reviews1
Growth hormone-releasing hormone increases somatotrope proliferation.
“growth hormone releasing hormone (GHRH): 1) stimulates GH release and synthesis from pituitary growth hormone (GH)-producing cells (somatotropes), 2) drives somatotrope proliferation”
Review
Update on regulation of GHRH and its actions on GH secretion in health and disease
Reviews in endocrine & metabolic disorders
Growth hormone
upin reviews1
1 study
Growth hormone
upin reviews1
Growth hormone-releasing hormone increases growth hormone.
“growth hormone releasing hormone (GHRH): 1) stimulates GH release and synthesis from pituitary growth hormone (GH)-producing cells (somatotropes)”
Review
Update on regulation of GHRH and its actions on GH secretion in health and disease
Reviews in endocrine & metabolic disorders
Growth hormone secretion
upin humans1
1 study
Growth hormone secretion
upin humans1
Growth hormone-releasing hormone increases growth hormone secretion in humans.
“Graded boluses of GHRH elicited dose-dependent GH responses, with no difference between the two age groups.”
Human trialhealthy mengraded bolusesmales
The Journal of clinical endocrinology and metabolism
GH secretion
upin humans1
1 study
GH secretion
upin humans1
Growth hormone-releasing hormone increases GH secretion in humans (GH response: 183.8, 260.9 and 356.1 micrograms/L/h at 1.0, 2.0 and 3.0 micrograms/kg).
“In E the GH response to 3 micrograms/kg HEX or GHRH were clearly higher than those to 2 micrograms/kg.”
Human trialIncreasing growth hormone-releasing hormone doses1.0, 2.0 and 3.0 micrograms/kgn = 16
Pituitary
Growth hormone release
upin rat cells1
1 study
Growth hormone release
upin rat cells1
Growth hormone-releasing hormone increases growth hormone release in rat cells.
“GRF stimulated GH release from LD- and HD-somatotropes, and the GRF responsiveness was similar in both subpopulations and in all ages.”
Cellspituitarymales
Molecular and cellular endocrinology
Fasting glucose
no changein humans1
1 study
Fasting glucose
no changein humans1
Growth hormone-releasing hormone has no effect on fasting glucose in humans.
“GHRH treatment did not affect fasting glucose, urinary C-peptide, blood pressure, or chemistry and hematology profiles.”
Human trialHealthy nonobese old men14 daysmalesn = 10
The Journal of clinical endocrinology and metabolism
Phosphate
upin humans1
1 study
Phosphate
upin humans1
Growth hormone-releasing hormone increases phosphate in humans.
“Phosphate levels increased (P less than 0.05) during GHRH treatment.”
Human trialHealthy nonobese old men14 daysmalesn = 10
The Journal of clinical endocrinology and metabolism
GH and IGF-I
upin humans1
1 study
GH and IGF-I
upin humans1
Growth hormone-releasing hormone increases GH and IGF-I in humans.
“Thus, short term sc administration of GHRH to healthy old men reverses age-related decreases in GH and IGF-I”
Human trialHealthy nonobese old men; compared with baseline1 mg twice daily14 daysmalesn = 10
The Journal of clinical endocrinology and metabolism
What is Growth hormone-releasing hormone linked with?
1Studies link Growth hormone-releasing hormone with 1 measure, most often growth hormone response to growth hormone-releasing hormone (1 study).
Growth hormone response to growth hormone-releasing hormone
mixedin humans1
1 study
Growth hormone response to growth hormone-releasing hormone
mixedin humans1
Growth hormone-releasing hormone is associated with growth hormone response to growth hormone-releasing hormone in humans (One normal response (> 10 ng/ml) after 1 week; one near-normal response (9.7 ng/ml) after 2 weeks; one impaired response (3.2 ng/ml) after 2 weeks).
“One exhibited a normal response (> 10 ng/ml) after 1 week of daily GHRH treatment, another had a near-normal response after 2 weeks (9.7 ng/ml)”
Human trialInitially impaired GH response to intravenous GHRH100 micrograms subcutaneously twice dailyUp to 2 weeksmalesn = 3
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
More on Growth hormone response to growth hormone-releasing hormone
What acts on Growth hormone-releasing hormone?
1Studies name 1 thing that act on Growth hormone-releasing hormone, most often somatostatin (1 study).
Somatostatin
downin reviews1
1 study
Somatostatin
downin reviews1
Somatostatin inhibits growth hormone-releasing hormone.
“is negatively regulated by somatostatin (SST), GH and IGF1”
Review
Update on regulation of GHRH and its actions on GH secretion in health and disease
Reviews in endocrine & metabolic disorders
Funding
1 grant since 2018National Institute of Diabetes and Digestive and Kidney DiseasesUS$4m