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Proteomic age clock

There are 4 papers on proteomic age clock in aging research: 4 observational studies in people. The newest story, Nov 9, 2026: “Exenatide lowered protein-based age scores in people”.

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5 new papers in 30 daysSee all 53 papers on proteomic age clock

“identifying 25 independent exposures associated with mortality and proteomic aging.”
Integrating the environmental and genetic architectures of aging and mortalityNature medicine2025doi:10.1038/s41591-024-03483-9
  • Humans4

Associations

5

Environmental exposures

upin humans1

1 study

  1. Environmental exposures are associated with proteomic age clock in humans.

    “identifying 25 independent exposures associated with mortality and proteomic aging.”

    Humansn = 45,441

    Integrating the environmental and genetic architectures of aging and mortality

    Nature medicine

More on Environmental exposures

Frailty index

upin humans1

1 study

  1. Proteomic age clock is associated with frailty index in humans.

    “Proteomic aging was also associated with age-related measures of biological, physical and cognitive function, including telomere length, frailty index and reaction time.”

    Humans

    Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

    Nature medicine

More on Frailty index

Mortality

upin humans1

1 study

  1. Proteomic age clock is linked with a higher risk of mortality in humans.

    “proteomic aging was associated with the incidence of 18 major chronic diseases (including diseases of the heart, liver, kidney and lung, diabetes, neurodegeneration and cancer), as well as with multimorbidity and all-cause mortality risk.”

    Humans

    Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

    Nature medicine

Chronic disease

upin humans1

1 study

  1. Proteomic age clock is linked with a higher risk of chronic disease in humans (18 major chronic diseases).

    “proteomic aging was associated with the incidence of 18 major chronic diseases”

    Humans

    Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

    Nature medicine

More on Chronic disease

Chronological age

upin humans1

1 study

  1. Proteomic age clock predicts chronological age in humans (r = 0.94).

    “We identified 204 proteins that accurately predict chronological age (Pearson r = 0.94)”

    Humansn = 45,441

    Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

    Nature medicine

Latest

Dec 2025: 5Jan 2026: 1Feb 2026: 2Mar 2026: 1Apr 2026: 3May 2026: 1Jun 2026: 3Jul 2026: 2Aug 2026: 4Sep 2026: 4Oct 2026: 5Nov 2026: 233 papers in 12 months
AHA Scientific Sessions 2026 Abstract

Exenatide lowered protein-based age scores in people

Over 12 months, exenatide lowered six organ-related age scores and limited a liver score’s rise compared with placebo in people with type 2 diabetes.Over 12 months, exenatide lowered six organ-related age scores and limited a liver score’s rise compared with placebo in people with type 2 diabetes.

Randomized trial · 3,973 peopleExenatide
Paper
AHA Scientific Sessions 2026 Abstract

Protein-based age measures differ by heart failure type

A retrospective comparison of 269 people with one heart failure form, 275 with another and 186 controls found different protein-based aging patterns.A retrospective comparison of 269 people with one heart failure form, 275 with another and 186 controls found different protein-based aging patterns.

Cohort studyHeart failure
Paper
bioRxiv

Age-linked protein patterns differ among organs in mice

Models built from protein measurements in eight mouse organs tracked age in independent groups but transferred poorly from one organ to another.Models built from protein measurements in eight mouse organs tracked age in independent groups but transferred poorly from one organ to another.

Preprint: computational studyBiomarkers
Paper
medRxiv

Protein-based aging clocks linked to death risk in Finnish twins

Fifteen protein-based aging clocks were linked to death from any cause; 11 remained associated after lifestyle adjustment in 401 Finnish twins.Fifteen protein-based aging clocks were linked to death from any cause; 11 remained associated after lifestyle adjustment in 401 Finnish twins.

Preprint: cohort · 401 peopleBiomarkers
Paper
bioRxiv

Lifelong mating reshaped liver aging in short-lived killifish

In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several…In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several liver cell types.

Preprint: fish studyInterventions
Paper
bioRxiv

Blood protein clock tracks shifts in health risks over time

In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.

Preprint: cohort study of 4,100 peopleBiomarkers
Paper

See all 53 papers on proteomic age clock

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