Papers on PPARα

172 papers11 new in 30 days

Wednesday, April 15

AgingApr 15

Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence

Experiments in cellsMechanisms

Paper

Wednesday, April 1

GeroScienceApr 1

Developmental exposure to Δ⁹-tetrahydrocannabinol (THC) causes biphasic effects on longevity, inflammation, and reproduction in aged zebrafish (Danio rerio)

Experiments in zebrafishInterventions

Paper

Thursday, March 5

Frontiers in EndocrinologyMar 5

An Integrated Analysis of mRNA and lncRNA Expression Profiles Indicates Their Potential Contribution to Brown Fat Dysfunction With Aging

Experiments in miceMechanisms

Paper

Saturday, February 15

Biochimica et Biophysica Acta Molecular Basis of DiseaseFeb 15

Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice

Experiments in miceInterventions

Paper

Saturday, November 23

Life SciencesNov 23

Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway

Experiments in miceVitamin D

Paper

Saturday, October 12

The Journals of Gerontology, Series AOct 12

NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity

Experiments in miceInterventions

Paper

Saturday, October 5

Frontiers in BioscienceOct 5

Resveratrol reverts Streptozotocin-induced diabetic nephropathy

Experiments in animalsInterventions

Paper

Saturday, August 24

CellAug 24

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

Experiments in animalsInterventions

Paper

Wednesday, July 10

EBioMedicineJul 10

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Study in peopleFibrates

Paper

Sunday, July 7

BMJ OpenJul 7

The effect of resveratrol supplementation on the expression levels of factors associated with cellular senescence and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: study protocol for a double-blind controlled randomised clinical trial

Study protocolResveratrol

Paper

Wednesday, May 22

The Journals of Gerontology, Series AMay 22

PPARα/β Activation Alleviates Age-Associated Renal Fibrosis in Sprague Dawley Rats

Experiments in ratsRenal fibrosis

Paper

Thursday, May 16

Molecular NeurobiologyMay 16

Effect of Initial Aging and High-Fat/High-Fructose Diet on Mitochondrial Bioenergetics and Oxidative Status in Rat Brain

Experiments in ratsMitochondrion

Paper

Thursday, April 4

International Journal of Molecular SciencesApr 4

2, 3, 4', 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL Receptor Knockout Mice and Its Possible Mechanisms

Experiments in miceMetabolic dysfunction-associated steatohepatitis

Paper

Tuesday, April 2

bioRxivApr 2

Temporal gating of SIRT1 functions by O-GlcNAcylation prevents hyperglycemia and enables physiological transitions in liver

Preprint: experiments in animalsSirtuin signaling

Paper

Tuesday, March 26

Cellular Physiology and BiochemistryMar 26

Mitochondrial Protection Partly Mitigates Kidney Cellular Senescence in Swine Atherosclerotic Renal Artery Stenosis

Experiments in 6 pigsKidney

Paper

Friday, November 9

Toxicology and Applied PharmacologyNov 9

6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction

Experiments in animalsInterventions

Paper

Saturday, October 6

NutrientsOct 6

Do the Effects of Resveratrol on Thermogenic and Oxidative Capacities in IBAT and Skeletal Muscle Depend on Feeding Conditions?

Experiments in ratsResveratrol

Paper

Friday, August 31

Journal of Lipid ResearchAug 31

Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice

Experiments in animalsMechanisms

Paper

Monday, July 30

FEBS Open BioJul 30

2D DIGE proteomic analysis reveals fasting-induced protein remodeling through organ-specific transcription factor(s) in mice

Experiments in miceFasting

Paper

Sunday, July 29

Scientific ReportsJul 29

Complementary intestinal mucosa and microbiota responses to caloric restriction

Experiments in miceDietary restriction

Paper

Sunday, June 17

The Journal of Clinical InvestigationJun 17

Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid β-oxidation

Experiments in miceFatty acid β-oxidation

Paper

Tuesday, April 24

Scientific ReportsApr 24

Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia

Experiments in miceMechanisms

Paper

Tuesday, April 17

Aging CellApr 17

Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway

Experiments in miceDiabetic cardiomyopathy

Paper

Wednesday, March 7

Aging CellMar 7

NHR-49/HNF4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting

Experiments in wormsOxidative stress and ROS signaling

Paper

Monday, February 12

Journal of the American Society of NephrologyFeb 12

Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

Experiments in ratsFatty acid β-oxidation

Paper

Tuesday, November 28

Journal of Interferon & Cytokine ResearchNov 28

Interleukin-6 Affects Aging-Related Changes of the PPARα-PGC-1α Axis in the Myocardium

Experiments in miceMechanisms

Paper

Sunday, October 8

Biochimica et Biophysica Acta Molecular and Cell Biology of LipidsOct 8

Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice

Experiments in miceMechanisms

Paper

Monday, September 11

Journal of the Formosan Medical AssociationSep 11

High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats

Experiments in ratsMechanisms

Paper

Tuesday, September 5

Cell MetabolismSep 5

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

Experiments in miceKetogenic diet

Paper

Monday, August 28

Experimental GerontologyAug 28

An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8

Experiments in miceLipid and ceramide metabolism

Paper