Plasma lactate

1. Resveratrol + exercise training decreases plasma lactate in mice.

   “plasma lactate and ammonia levels of the ET + RES group after acute swimming exercise were significantly lower compared to the OC group”

   AnimalsAfter acute swimming exercise, compared with older controlplasma4 weeks

   Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice

   Molecules (Basel, Switzerland)·May 18, 2016

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1. PDH phosphorylation is associated with plasma lactate in humans.

   “Changes in insulin-stimulated PDH phosphorylation were positively related to changes in plasma lactate.”

   Human trialchanges during insulin stimulation

   Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training

   American journal of physiology. Endocrinology and metabolism·May 24, 2016

More on PDH phosphorylation

1. Older age is associated with plasma lactate in humans.

   “In response to insulin, plasma lactate was elevated in aged individuals when normalized to insulin action.”

   Human trialin response to insulin, normalized to insulin action; compared with young individualsplasman = 20

   Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training

   American journal of physiology. Endocrinology and metabolism·May 24, 2016