Journal of Applied Physiology
No added kidney injury seen in aging castrated rats given estrogen
An experiment in aging male rats, with 10 per group, suggested no increased kidney injury after 38–44 weeks of hormone exposure; kidney function remained unclear.An experiment in aging male rats, with 10 per group, suggested no increased kidney injury after 38–44 weeks of hormone exposure; kidney function remained unclear.
Rat studyKidney disease
Who was studiedMale Sprague-Dawley rats, 9 mo, against age-matched male controls
What changedProteinuria, proximal tubule injury markers, and glomerular injury scores were lower than in controls
The catchEstrogen was combined with castration, so the study did not isolate estrogen effects