bioRxiv
Progeria disrupts cells in the intestinal lining in mice
Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.
Preprint: experiments in heterozygous progeria miceLMNA
Limit: The link between mitochondrial dysfunction and impaired cell maturation remains a proposed model