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Wednesday, October 28

Neurobiology of Aging

Older adults show stronger brain tracking of speech

A listening experiment with 83 younger and older adults found greater noise-related reductions in brain tracking among older listeners.A listening experiment with 83 younger and older adults found greater noise-related reductions in brain tracking among older listeners.

Cross-sectional · 83 peopleMechanisms
Paper
Research Square

Stronger grip linked to brain structure in midlife and later life

With measurements on comparable scales, each unit of greater grip strength was linked to a 0.117-unit decrease in a brain scan marker of injury.With measurements on comparable scales, each unit of greater grip strength was linked to a 0.117-unit decrease in a brain scan marker of injury.

Flowchart of the study population
Preprint: cross-sectional · 2,618 peoplePopulations
Paper
Research Square

Deleting an immune-related gene eased bone loss in female mice

An experiment compared female mice with and without an immune-regulating gene after ovary removal, finding higher bone density in mice without it.An experiment compared female mice with and without an immune-regulating gene after ovary removal, finding higher bone density in mice without it.

Crlf2 is highly expressed in osteoporosis samples and osteoclasts, and is lowly expressed in osteoblasts.
Preprint: mouse studyBones and joints
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Research Square

Higher immune age linked to lower vaccine antibody levels

In an observational preprint involving 658 fully vaccinated adults, both higher immune-age scores and older age were linked to lower antibody levels after COVID-19…In an observational preprint involving 658 fully vaccinated adults, both higher immune-age scores and older age were linked to lower antibody levels after COVID-19 vaccination.

(A) Bivariate association of anti-RBD titers of the eligible observations from the general population (N=567) with chronological age.
Preprint: cross-sectional · 658 peopleBiomarkers
Paper
Research Square

Kidney test gap linked to developing multiple chronic diseases

A negative gap between kidney-function estimates was linked to progression from one disease to multiple conditions, with a hazard ratio of 1.12 versus the reference…A negative gap between kidney-function estimates was linked to progression from one disease to multiple conditions, with a hazard ratio of 1.12 versus the reference category.

Numbers (percentages) of participants in five transition stages of transition pattern A*.
Preprint: cohort · 324,820 peopleKidney
Paper
Research Square

Heatwaves linked to faster cognitive aging in Chinese adults

Each additional 10 heatwave days was linked to a steeper age-related decline in cognitive scores, by 0.020 standard deviations per decade.Each additional 10 heatwave days was linked to a steeper age-related decline in cognitive scores, by 0.020 standard deviations per decade.

Heatwave effect on cognitive z-score by age and education.
Preprint: cohort · 13,741 peoplePopulations
Paper
Interactive Learning Environments

AI interaction linked to less digital loneliness in older adults

A four-week randomized trial of 90 older adults found a greater decline in digital loneliness with AI-assisted interaction than with conventional interaction.A four-week randomized trial of 90 older adults found a greater decline in digital loneliness with AI-assisted interaction than with conventional interaction.

Older adults gather around a tablet amid many speech bubbles, while gray figures stand farther apart around another tablet with fewer bubbles.
Randomized trial · 90 peopleInterventions
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