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Wednesday, October 28

Diabetes Care

Blood sugar fell in adults with type 1 diabetes and excess weight

A measure of longer-term blood sugar fell 0.4 to 0.6 percentage points with acmopatide versus 0.3 points with placebo over 16 weeks.A measure of longer-term blood sugar fell 0.4 to 0.6 percentage points with acmopatide versus 0.3 points with placebo over 16 weeks.

Blood cells beside small adult figures show sparse sugar particles around dark blue-green cells and denser particles around gray cells.
Randomized trial · 111 peopleType 1 diabetes
Paper
Brain Communications

Strength training showed no clear overall effect on brain lesions

After 12 months, whole-brain lesion volume differed by minus 0.016 log-transformed cubic centimeters versus balance and tone exercises, with no clear group difference.After 12 months, whole-brain lesion volume differed by minus 0.016 log-transformed cubic centimeters versus balance and tone exercises, with no clear group difference.

Randomized trial · 89 peopleResistance training
Paper
medRxiv

Combined biological scores link to heart risks across ancestries

For cardiovascular death, a measure of how well scores separated cases from noncases was 0.83 for the combined score versus 0.78 for a clinical model.For cardiovascular death, a measure of how well scores separated cases from noncases was 0.83 for the combined score versus 0.78 for a clinical model.

A cutaway heart with a cracked gray patch sits beside intact heart muscle, folded proteins in blood plasma, and a group of small upright figures.
Preprint: cohort studyBiomarkers
Paper
medRxiv

Blood traces in negative stool tests link to bowel cancer risk

Two-year bowel cancer risk was 504.5 per 100,000 episodes for stool hemoglobin of 15 to under 20 micrograms per gram against 35.7 for 0 to 5.Two-year bowel cancer risk was 504.5 per 100,000 episodes for stool hemoglobin of 15 to under 20 micrograms per gram against 35.7 for 0 to 5.

An opened bowel with a dark growth sits beside stool rich in blood cells; a smaller, smooth bowel section has stool with fewer blood cells.
Preprint: cohort · 700,734 peopleBiomarkers
Paper
medRxiv

Five risk factors linked to cognitive scores, not decline

An observational study followed 1,396 generally healthy adults aged 36–108 for an average of 5.0 years, separating cognitive performance from subsequent decline.An observational study followed 1,396 generally healthy adults aged 36–108 for an average of 5.0 years, separating cognitive performance from subsequent decline.

Blood plasma pools contain dense versus sparse dark protein forms, with small upright, faceless people gathered around each sample.
Preprint: cohort · 1,396 peoplePopulations
Paper
NPJ Aging

Leisure activities link to cognitive resilience by gender

In 3,293 older Chinese adults followed from 2011 to 2020, mental activities linked to cognitive resilience in both genders, but social links were concentrated in men.In 3,293 older Chinese adults followed from 2011 to 2020, mental activities linked to cognitive resilience in both genders, but social links were concentrated in men.

Cohort · 3,293 peoplePopulations
Paper