P53 protein

There are 22 papers on P53 protein in aging research: 1 trial and 2 observational studies in people, 8 in animals, 11 in cells.

22 papers study it72 more mention it1 finding

3 new papers in 30 daysSee all 94 papers on P53 protein

Human trial1
Humans2
Animals8
Cells11

Upstream

1

IL-6

upin mice1

1 study

IL-6 increases P53 protein in old mice, shown by Il6 knockout.
“it was significantly higher in old wild-type hearts than in old IL6 knockout hearts (p < .05)”
Animalsin old mice, shown by Il6 knockoutmyocardiummales
Interleukin 6 Knockout Inhibits Aging-Related Accumulation of p53 in the Mouse Myocardium
The journals of gerontology. Series A, Biological sciences and medical sciencesMay 3, 2018

Latest

12 papers in 12 months

European Journal of Applied PhysiologyOct 29

Association between atherogenic risk-modulating proteins and endothelium-dependent flow-mediated dilation in coronary artery disease patients

Cross-sectional study of 56 peopleMechanisms

bioRxivApr 5

3’UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity

Preprint: experiments in cellsTP53

Experimental Cell ResearchFeb 13

Resistance to mutant KRASV12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line

Experiments in human cellsCellular senescence

Iranian Journal of Basic Medical SciencesOct 12

Telomerase activator-65 and pomegranate peel improved the health status of the liver in aged rats; multi-targets involved

Experiments in ratsInterventions

Nature CommunicationsAug 22

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Experiments in miceTP53

Cell and Tissue ResearchJul 6

Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence

Experiments in miceCellular senescence

Cell & BioscienceJun 9

Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

Experiments in cellsSpermidine

Experimental GerontologyMay 23

Sargahydroquinoic acid (SHQA) suppresses cellular senescence through Akt/mTOR signaling pathway

Experiments in human cellsInterventions

Stem Cells InternationalFeb 20

Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy

Experiments in rat cellsRapamycin

Molecular and Cellular BiochemistryOct 29

Trehalose alleviates oxidative stress-induced senescence and is associated with cell-cycle remodeling

Experiments in miceInterventions

See all 94 papers on P53 protein