There are 5 papers on oxidized RNA in aging research: 1 observational study in people, 2 in animals, 2 in cells.
5 papers study it3 more mention it3 findings
See all 8 papers on oxidized RNA
“high RNA oxidation was associated with long-term all-cause mortality, independent of adjustment for age, medical history and sepsis severity (HR 1.29 [(1.17-1.41, 95% CI] p < 0.01).”
- Humans1
- Animals2
- Cells2
Interventions
2Antioxidants
downin yeast cells1
1 study
Antioxidants
downin yeast cells1
Antioxidants decrease oxidized RNA in Kllsm4Δ1 mutant cells.
“Lowering intracellular ROS levels by antioxidants recovers the wild-type phenotype of mutant cells, including reduced amount of oxidized RNAs and lower mutation rate.”
Cellsin Kllsm4Δ1 mutant cells
Apoptosis : an international journal on programmed cell death
Acetyl-L-carnitine + r-alpha-lipoic acid
downin rats1
1 study
Acetyl-L-carnitine + r-alpha-lipoic acid
downin rats1
Acetyl-L-carnitine + r-alpha-lipoic acid decreases oxidized RNA in rats (ALCAR and/or LA supplementation; combination most effective).
“Dietary administration of ALCAR and/or LA significantly reduced the extent of oxidized RNA, the combination being the most effective.”
AnimalsALCAR and/or LA supplementation; combination most effectivehippocampus
Proceedings of the National Academy of Sciences of the United States of America
Associations
1Mortality
upin humans1HR 1.29
1 study
Mortality
upin humans1HR 1.29
Oxidized RNA is linked with a higher risk of mortality in humans (patients with sepsis) (HR 1.29 [(1.17-1.41, 95% CI] p < 0.01).
“high RNA oxidation was associated with long-term all-cause mortality, independent of adjustment for age, medical history and sepsis severity (HR 1.29 [(1.17-1.41, 95% CI] p < 0.01).”
Humanspatients with sepsis
Free radical biology & medicine