Oxidized mtDNA

2 papers2 findings

Animals1

Effects

1

Macrophage pyroptosis

upin mice1

1 study

Oxidized mtDNA induces macrophage pyroptosis in mice.
“aging triggered mitochondrial permeability transition pore (mPTP) channel opening to promote the release of Oxidized mtDNA (Ox-mtDNA), thereby inducing macrophage pyroptosis.”
Animalsin aged liver during IRI
Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake
Cell death discovery7 Oct 2025

More on Macrophage pyroptosis

Upstream

1

MCU

upin mice1

1 study

MCU increases oxidized mtDNA in mice.
“Calcium uptake via acetylated MCU triggered mPTP channel opening, which is an important mechanism for Ox-mtDNA release from mitochondria into the cytoplasm.”
Animalsin liver IRI
Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake
Cell death discovery7 Oct 2025

Latest

1 in 12 months

Frontiers in Cell and Developmental Biology2 Mar

Hepatic mitochondrial signaling as a systemic hub: inter-organ communication networks in aging and aging-related diseases

ReviewOxidative stress and ROS signalling

Cell Death Discovery8 Oct

Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake

Experiments in micePyroptosis