Macrophage pyroptosis

1 paper1 finding

Animals1

Upstream

1

Oxidized mtDNA

upin mice1

1 study

Oxidized mtDNA induces macrophage pyroptosis in mice.
“aging triggered mitochondrial permeability transition pore (mPTP) channel opening to promote the release of Oxidized mtDNA (Ox-mtDNA), thereby inducing macrophage pyroptosis.”
Animalsin aged liver during IRI
Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake
Cell death discovery7 Oct 2025

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Cell Death Discovery8 Oct

Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake

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