Neuromelanin

2 papers1 finding

Effects

1

Inflammation

upin mice1

1 study

Neuromelanin activates inflammation in mice.
“NM consistently upregulated neuroinflammatory pathways”
Animalsin catecholaminergic neurons
Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
bioRxiv7 Aug 2026Preprint

More on Inflammation

Funding

1 grant since 2025

National Institute on AgingUS$830.8k

Impact of neuromelanin and Tau accumulation during aging and disease on local gene expression in the human locus coeruleus using spatially-resolved transcriptomics with protein detection
National Institute on AgingLieber InstituteUS$830.8k2024–2029

Latest

6 in 12 months

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Motor System Neurodegeneration in Aging and Synucleinopathies: Circuit Vulnerability and Neuroimaging Biomarkers

ReviewMechanisms

medRxiv31 Aug

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AAIC 2025 Abstract7 Jan

PET/MR imaging of LC‐NE function for interrogation of health disparity in preclinical AD

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AAIC 2025 Abstract23 Dec

PET/MR imaging of LC‐NE function for interrogation of health disparity in preclinical AD

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AAIC 2025 Abstract23 Dec

Locus coeruleus structural integrity relates to cortical amyloid and tau pathology in vivo

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AAIC 2025 Abstract23 Dec

Locus coeruleus structural integrity relates to cortical amyloid and tau pathology in vivo

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Frontiers in Neuroscience5 Jul

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

ReviewMechanisms

Cellular and Molecular Life Sciences1 Jun

The comparative biology of neuromelanin and lipofuscin in the human brain

ReviewMechanisms