Locus coeruleus structural integrity relates to cortical amyloid and tau pathology in vivo

Abstract

Background: The locus coeruleus (LC) is one of the first epicentres of tau pathology in Alzheimer’s disease, displaying pathology decades before clinical symptom onset. We investigated whether LC integrity was associated with cortical deposition of amyloid and tau in vivo in asymptomatic, at‐risk older adults.