Azadiradione

1. Azadiradione activates HSF1 in mice.

   “upregulation and activation of not only HSF1 (master regulator of protein folding) but also Ube3a”

   AnimalsHD micebrain

   Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease

   Molecular neurobiology·2 Jan 2018

More on HSF1

1. Azadiradione decreases mutant huntingtin aggregates load in mice.

   “Azadiradione-treated HD mice brain also exhibited considerable decrease in mutant huntingtin aggregates load”

   AnimalsHD micebrain

   Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease

   Molecular neurobiology·2 Jan 2018

More on Mutant huntingtin aggregates load

1. Azadiradione decreases deterioration in body weight in mice.

   “Prolonged treatment of azadiradione to HD mice significantly improved the progressive deterioration in body weight”

   AnimalsHD mice

   Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease

   Molecular neurobiology·2 Jan 2018

1. Azadiradione improves motor functioning in mice.

   “Prolonged treatment of azadiradione to HD mice significantly improved the progressive deterioration in body weight, motor functioning”

   AnimalsHD mice

   Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease

   Molecular neurobiology·2 Jan 2018

1. Azadiradione extends lifespan in mice.

   “extension of lifespan”

   AnimalsHD mice

   Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease

   Molecular neurobiology·2 Jan 2018