Muscle protein fractional synthetic rate

1. Amino acids increase muscle protein fractional synthetic rate in humans.

   “A significant main effect of time (p ≤ 0.001) was observed for the increase in muscle FSR (0.0568 ± 0.0338%/h) from the post-absorptive state to the post-prandial state.”

   Human trialn = 12

   Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals

   Frontiers in nutrition·Mar 8, 2024

2. Amino acids increase muscle protein fractional synthetic rate in humans (0.058%/hour over 3 h).

   “Muscle protein FSR increased 0.058%/hour over 3 h following consumption.”

   Human trialmuscle3.6 g3 h

   Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals

   Frontiers in nutrition·Mar 8, 2024

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1. Cafeteria diet showed no clear effect on muscle protein fractional synthetic rate in rats.

   “Gastrocnemius protein fractional synthetic rates in response to either an acute leucine bolus or two weeks of feeding were equivalent across groups irrespective of age or diet.”

   Animalsgastrocnemius

   Cafeteria Diet Impacts the Body Weight and Energy Expenditure of Brown Norway Rats in an Apparent Age Dependent Manner, but Has no Effect on Muscle Anabolic Sensitivity to Nutrition

   Frontiers in nutrition·Sep 9, 2021

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1. Fortetropin increases muscle protein fractional synthetic rate in humans (compared with placebo (cheese powder)) (18% vs placebo).

   “The overall magnitude of the difference in muscle protein FSR of Fortetropin from placebo was 18%, with multiple gene ontologies affected.”

   Human trialcompared with placebo (cheese powder)proteo-lipid complex made from fertilized egg yolkvastus lateralis19.8 g/d21 days

   Effects of Fortetropin on the Rate of Muscle Protein Synthesis in Older Men and Women: A Randomized, Double-Blinded, Placebo-Controlled Study

   The journals of gerontology. Series A, Biological sciences and medical sciences·Jul 1, 2020

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1. C-reactive protein decreases muscle protein fractional synthetic rate in human cells.

   “a CRP-mediated reduction (p < 0.05) in muscle protein fractional synthetic rate of human myotubes exposed to CRP for 24 h.”

   Cellsmyotube24 h

   Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly

   Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology·Nov 9, 2017

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