C-reactive protein

Q: What is C-reactive protein linked with?

Studies link C-reactive protein with 1 measure, most often type 2 diabetes (1 study).

Q: Has C-reactive protein been tested in people?

Yes: 11 observational studies in people have been published, and 4 trials are registered.

C-reactive protein has been studied in 12 papers since 2017: 11 observational studies in people, 1 review; 3 in the past year. The newest paper, Oct 26, 2026: “CRP reveals an inflammatory, non-calcified coronary endotype in SMuRF-less individuals and enables efficient two-stage screening for subclinical atherosclerosis”.

Intervention Human trials

12 papers study it7 findingsUpdated Oct 26, 2026

MeSH

1 new paper in 30 daysSee all 12

“No significant causal effects were observed for CRP or GDF-15.”

Causal effects of inflammation on long-term mortality: A mendelian randomization studyAging2026doi:10.18632/aging.206352

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

About aging: trials about aging, of every trial that tests the drug for any use.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

5 independent labs in 3 countries
4 trials, none about aging, 2 with no results posted

Funders: Anhui Provincial Department of Science and Technology and 6 more
1 of 7 findings with company ties

Humans11

What did studies of C-reactive protein find?

Studies of C-reactive protein measured 6 outcomes; the most studied are mortality (1 study), biological aging acceleration (1) and telomere length (1).

Mortality

no changein humans1

1 study

C-reactive protein was not clearly linked with mortality in humans (genetically proxied levels, Mendelian randomization).
“No significant causal effects were observed for CRP or GDF-15.”
Humansgenetically proxied levels, Mendelian randomizationgenetically proxied levels
Causal effects of inflammation on long-term mortality: A mendelian randomization study
AgingFeb 6, 2026

Biological aging acceleration

upin humans1

1 study

C-reactive protein is linked with higher biological aging acceleration in humans (high CRP (>3 mg/L), with or without DM, relative to the CRPlow/non-DM reference group).
“the CRPhigh/non-DM, CRPlow/DM, and CRPhigh/DM groups had significantly advanced biological ageing”
Humanshigh CRP (>3 mg/L), with or without DM, relative to the CRPlow/non-DM reference group
Joint association of diabetes mellitus and inflammation status with biological ageing acceleration and premature mortality
Diabetes & metabolic syndromeMay 31, 2024

What is C-reactive protein linked with?

Studies link C-reactive protein with 1 measure, most often type 2 diabetes (1 study).

Type 2 diabetes

upin humans1HR 3.63

1 study

C-reactive protein is linked with a higher risk of type 2 diabetes in humans (joint high CRP and high TyG exposure) (HR 3.63 (95% CI 3.35-3.93) versus reference).
“participants with both high CRP and high TyG had the greatest risks across outcomes”
Humansjoint high CRP and high TyG exposure
Associations of C-reactive protein, triglyceride-glucose index, and the C-reactive protein-triglyceride glucose index with multistate trajectories in the cardiovascular-renal-diabetes cluster
Frontiers in endocrinologyMar 16, 2026