1 paper1 finding
Childhood adversity
upin humans1
Childhood adversity is associated with metabolomic ageing in humans.
“Childhood adversity was more strongly associated with multiple ageing markers in females, including a metabolite-predicted age exceeding chronological age”
HumansStronger association in females than malesn = 153,557
Sex differences in associations between adversity and biological ageing
medRxiv29 Aug 2025Preprint
In over 400,000 UK Biobank participants, an NMR metabolomic aging score tracked mortality and pinpointed six candidate causal plasma proteins across adulthood.In over 400,000 UK Biobank participants, an NMR metabolomic aging score tracked mortality and pinpointed six candidate causal plasma proteins across adulthood.
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.