Meta polygenic risk score

Longevity is associated with meta polygenic risk score in humans (AUC = 0.64, p = 6.45 × 10−15).

“We combined the individual ARD-PRSs into a meta-PRS (AUC = 0.64, p = 6.45 × 10−15).”

Humanscompared to younger controls

Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score

International journal of molecular sciences·Sep 19, 2022