Age-related disease polygenic risk score

Longevity is associated with age-related disease polygenic risk score in humans (AUCs: ISS = 0.59, AD = 0.59, AF = 0.57, CAD = 0.56, CRC = 0.52, PD = 0.52, T2D = 0.51).

“For all ARD-PRSs tested, the LLI had significantly lower scores than the younger control individuals”

Humanscompared to younger controls

Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score

International journal of molecular sciences·Sep 19, 2022