MED12 mutation frequency

1. Oxidative stress and ROS signalling increases MED12 mutation frequency in mice.

   “Xenografts of primary myometrial cells subjected to prolonged oxidative stress demonstrated similar molecular responses and showed an increased frequency of MED12 mutations.”

   AnimalsXenografts in immunocompromised miceprimary human myometrial cell xenograftsProlonged

   Human Myometrial Cell Fate under Chronic Oxidative Stress for Leiomyomagenesis

   Research square·20 Jul 2026Preprint

More on Oxidative stress and ROS signalling