Conversion of mild cognitive impairment to Alzheimer's disease dementia
↑upin humans1
1 study
Magnetic resonance imaging predicts conversion of mild cognitive impairment to Alzheimer's disease dementia in humans.
“Based on the current evidence available, MRI (specifically sMRI and DTI) has the highest predictive ability of MCI‐AD conversion in a clinical setting.”
In a brain-imaging experiment, memory-related activity reductions in several regions did not differ between younger and older adults completing an object-categorisation…In a brain-imaging experiment, memory-related activity reductions in several regions did not differ between younger and older adults completing an object-categorisation task.
Preprint: cross-sectional study in peopleMechanisms
Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.
Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.
A cross-sectional analysis of 59,269 UK Biobank participants found different metabolic associations depending on how fat-free mass was measured and fat around organs.A cross-sectional analysis of 59,269 UK Biobank participants found different metabolic associations depending on how fat-free mass was measured and fat around organs.
In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.