Magnetic resonance imaging

Biomarker

2 papers2 findings

MeSH D008279

  • Humans1

Effects

1

ROC-AUC

upin silico1

1 study
  1. Magnetic resonance imaging increases ROC-AUC in silico (+0.035 ROC-AUC (0.007 to 0.061)).

    “Against a matched clinical-only comparator, MRI raises logistic-regression ROC-AUC by 0.035 (exploratory interval 0.007 to 0.061)”

    In silicoagainst matched clinical-only comparator in logistic regressionn = 150

    How Reliable and Explainable Are Machine Learning Models for Dementia Detection? A Leakage-Aware Evaluation

    Research Square9 Sep 2026Preprint

Associations

1

Conversion of mild cognitive impairment to Alzheimer's disease dementia

upin humans1

1 study
  1. Magnetic resonance imaging predicts conversion of mild cognitive impairment to Alzheimer's disease dementia in humans.

    “Based on the current evidence available, MRI (specifically sMRI and DTI) has the highest predictive ability of MCI‐AD conversion in a clinical setting.”

    Reviewin a clinical setting

    Review: Efficacy of Neuroimaging Methods on the Prediction of Conversion from MCI to AD in a Clinical Setting

    AAIC 2025 abstract24 Dec 2025

More on Conversion of mild cognitive impairment to Alzheimer's disease dementia

Funding

8 grants since 2023

National Institute on AgingUS$1.8mNational Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$5.4mNational Institute of Mental HealthUS$3m

Latest

Nov 2025: 29Dec 2025: 89Jan 2026: 46Feb 2026: 15Mar 2026: 20Apr 2026: 0May 2026: 0Jun 2026: 2Jul 2026: 12Aug 2026: 84Sep 2026: 65Oct 2026: 17379 in 12 months
bioRxiv

Memory for links without conscious recall may stay intact with age

In a brain-imaging experiment, memory-related activity reductions in several regions did not differ between younger and older adults completing an object-categorisation…In a brain-imaging experiment, memory-related activity reductions in several regions did not differ between younger and older adults completing an object-categorisation task.

Preprint: cross-sectional study in peopleMechanisms
medRxiv

Brainstem MRI signal links to an Alzheimer's marker in adults

Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.

Preprint: cohort study of 163 peopleAlzheimer's disease
Medical Image Computing and Computer-assisted Intervention

Model estimates brain aging speed from local MRI changes

Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.

Computational studyBiomarkers
The Journal of Clinical Endocrinology and Metabolism

Fat-free mass links to metabolic health varied with deep belly fat

A cross-sectional analysis of 59,269 UK Biobank participants found different metabolic associations depending on how fat-free mass was measured and fat around organs.A cross-sectional analysis of 59,269 UK Biobank participants found different metabolic associations depending on how fat-free mass was measured and fat around organs.

Cross-sectional study of 59,269 peopleMetabolic syndrome
Food & Function

Gut metabolites linked to preserved brain thickness in older adults

In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.

Cohort study of 104 peopleInterventions