Lncrnas

Biomarker

3 papers4 findings

  • Humans1
  • Cells1

Effects

1

fibrosis

upin reviews1

1 study
  1. Lncrnas increase fibrosis.

    “In chronic kidney disease, cardiovascular disease, and pulmonary disorders, lncRNAs play a central role in promoting vascular dysfunction, endothelial cell aging, and fibrosis.”

    Review

    lncRNAs in vascular senescence and microvascular remodeling

    American journal of physiology. Heart and circulatory physiologyApr 18, 2025

Associations

3

Cellular senescence

upin reviews1

1 study
  1. Lncrnas are associated with cellular senescence.

    “Long noncoding RNAs (lncRNAs) have emerged as critical regulators of vascular senescence and microvascular remodeling, processes that significantly contribute to the development of age-related diseases”

    Review

    lncRNAs in vascular senescence and microvascular remodeling

    American journal of physiology. Heart and circulatory physiologyApr 18, 2025

More on Cellular senescence

Muscle atrophy

mixedin humans1

1 study
  1. Muscle atrophy is associated with lncrnas in humans.

    “A large number of long noncoding RNAs (lncRNAs) have been found to be abnormally expressed in atrophic muscles and dystrophic muscles”

    Reviewin atrophic muscles and dystrophic muscles

    Functions and Therapeutic Potentials of Long Noncoding RNA in Skeletal Muscle Atrophy and Dystrophy

    Journal of cachexia, sarcopenia and muscleMar 4, 2025

More on Muscle atrophy

cancer pathways

upin rhesus monkeys1

1 study
  1. Lncrnas are associated with cancer pathways in rhesus monkeys.

    “highly expressed lncRNAs are abundant during the key aging period and are associated with cancer pathways”

    Animals

    Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics

    BMC genomicsJun 26, 2024

Funding

1 grant since 2019

National Heart, Lung, and Blood InstituteUS$399.6k

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Research Square

Small RNA linked to death in younger people with COVID-19

In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00.In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00.

Preprint: study in peopleMechanisms